Project

TimeTeller

TimeTeller Logo
Keywords

Circadian Clock Profiling for Cancer Treatment Timing

Spin-Off

Project Website

The circadian clock is our internal time-generating system that rules our sleep/ wake cycles and molecular processes like metabolism and cell division. We all have our own personal circadian clock, which means metabolism and cell division happen at different times of day for each of us. Furthermore, over 50 % of FDA-approved drugs target 24h-rhythmic genes, but currently these circadian rhythms are not taken into consideration in clinical care.

Angela Relogio
Angela Relogio
(Charité)

Project Lead

The TimeTeller team has developed a non-invasive method to profile the personal circadian rhythm using an easy, risk-free at-home test, you send your samples to TimeTeller for analysis and predicting the optimal time windows for a given drug. The TimeTeller platform can ultimately be applied across clinical indications, from cancer to neurodegenerative diseases, diabetes and more, from pharma to clinic. The team is currently participating in clinical studies on ovarian and colon cancer and started studies in the field of pedriatic leukemia and Parkinson’s Disease.

Team TimeTeller combines the expertise of systems- and molecular biologists, computational scientists, a clinical trials assistant and a product developer. Timeteller is currently running a feasibility study at the Charité. Furthermore, the team is actively fundraising, looking for partnering in Pharma, and preparing to spin-off by the end of this year.

DHA

Project Lead

Angela Relogio

TimeTeller (Spin-Off)

„How can measuring the circadian rhythm help to reduce sideeffects of chemotherapy? To turn our research results into a medical application, we joined the BIH Digital Health Accelerator program in 2020. By now we have a working hardware and software prototypes, and cooperate with our clinical colleagues for validation. Apply to the DHA program if you want to bring your research results to healthcare systems.“

Angela Relogio

(Charité)